Understanding how myelin is generated

Myelin is an insulating layer that forms a sheath around nerves in the brain and spinal cord. It is critical for optimal brain function, enabling efficient conduction of nerve impulses to and from the brain and spinal cord. In MS, myelin is damaged, resulting in inability to conduct nerve impulses, and ultimately, loss of the underlying nerve fibres.  

Our understanding of how myelin is formed and maintained throughout life for optimal function is limited.  

This project aims to investigate how myelin-producing cells normally develop and generate myelin. In particular, the team will investigate a molecular signalling pathway called Erk1/2 to determine its role in myelin production, and how it is regulated at various stages of the process.  

To achieve this, Associate Professor Simon Murray will use a zebrafish laboratory model, which allows fluorescent imaging of the nerve growth processes at the single-cell level in the living organism.  

This project uses cutting-edge gene, molecular, and imaging technologies to identify the critically important cellular processes required to generate the myelin sheath in a living brain in real time.  

Outcomes of this project will deepen our understanding of how the brain normally develops and is maintained.  

Translation of the knowledge gained from this project could contribute to the development of new targeted therapies that may promote myelin repair, as well as improve learning, memory, and maintenance of the brain in older age. By exploring these possibilities, the research team aims to make significant contributions to the field of MS, ultimately enhancing the well-being and cognitive function of individuals living with MS.