Understanding the power of immune cells to induce neuroregeneration in MS

Multiple sclerosis (MS) is characterised by inflammation, loss of nerve protection (demyelination), and nerve cell damage (neurodegeneration). Currently, no treatment specifically reduces or reverses nerve-related disability in MS, representing a significant unmet need.

This project explores a potential new therapy using T-regulatory cells (Tregs), a type of immune cell. The research builds on previous findings showing that Tregs are replenished after autologous haematopoietic stem cell transplantation (AHSCT) in people with MS, a process believed to support long-term remission. Preliminary studies in laboratory models suggest Tregs may promote nerve repair, which this project aims to explore further.

Dr Malini Visweswaran and the team will examine whether Tregs from a person’s own cell transplant retain the ability to promote nerve repair, or if Tregs from people without MS might be more effective.

This research could pave the way for novel treatments targeting nerve repair to reduce disability in people with MS.